Miriam Margolyes stars in Give a Sh*t About Your Bowel ad campaign

The hilarious actress lends her voice to the final two of a three commercial series.

Produced by AIRBAG, the ads are running as part of Bowel Cancer Australia's Give a Sh*t About Your Bowel campaign, which has been launched in the lead up to Bowel Cancer Awareness Month.

When detected early, bowel cancer is one of Australia's most treatable cancers, yet it is Australia's second deadliest cancer and the deadliest for people aged 25-44.

Each year more than 15,500 people are diagnosed with the disease, with more than 5300 losing their lives.

In the third commercial, Miriam voices a bowel that has cancer, urging her human host to use their eyes to look in the toilet, hands to collect a stool sample and legs to 'trot off to the doctor'.

Miriam said she was thrilled to lend her voice to the important campaign.

"I'm not one to shy away from perceived 'taboo' topics and quite frankly, we need people to give a sh*t about bowel cancer," she said.

The commercial follows on from two previous commercials which focus on a polyp and bowel simultaneously.

Bowel Cancer Australia marketing and publicity manager Stephanie Bansemer-Brown said as a survivor herself, she knows all too well about the importance of a campaign that 'resonates'.

"Miriam's generosity in bringing the bowel to life coupled with the creative team at AIRBAG allowed us to create an advertising campaign with longevity that tackles the problem head on," she said.

Bowel Cancer Awareness Week takes place in June.

It is recommended that all people aged 50-74 take part in the national bowel cancer screening program. People in this age bracket will receive an at home testing kit in the mail once every two years. People aged 45-49 can request a screening kit from their GP.

Symptoms of bowel cancer can include:

For more information on bowel cancer click here.