New test could diagnose multiple infections

Aussie researchers develop fast new test for multiple infections including COVID-19

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Model of the c-FIND diagnostic device.

Model of the c-FIND diagnostic device.

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c-FIND is a test with the potential to rapidly and accurately detect multiple viral, bacterial or fungal infections within minutes.

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AUSTRALIAN researchers have developed a fast, new test for infections and infectious diseases, including COVID-19, which could allow doctors to quickly diagnose and treat patients.

Called c-FIND, the test has the potential to rapidly and accurately detect multiple viral, bacterial or fungal infections within minutes - much faster than existing tests which can take days, or even weeks, to return a result.

The test is now being developed into a portable, 'point-of-care' diagnostic device. Equipping clinicians with this device would enable them to diagnose infections without delay, and immediately provide the best care to high-risk patients, such as people with cancer.

The c-FIND research program is being led by the Walter and Eliza Hall Institute of Medical Research, in collaboration with Melbourne Health, Murdoch Children's Research Institute, Peter MacCallum Cancer Centre, The Royal Children's Hospital Melbourne, University of Melbourne, as well as industry partner and local biomedical technology company, Axxin Pty Ltd.

Following a successful bid for $1 million in funding from the Australian Government Medical Research Future Fund Frontiers program, the c-FIND research team is applying for funding that will include support for 13 clinical trials in Australian healthcare settings.

The trials aim to help advance Australia's ability to rapidly and accurately diagnose: COVID-19 and other existing and emerging biosecurity threats; high-risk cancer patients with asymptomatic or hard-to-detect infections; infections in infants and children; and latent tuberculosis.

Institute infectious disease physician and researcher Professor Marc Pellegrini said the c-FIND device could profoundly change how infections were detected and treated in a range of settings including hospitals, GP clinics, airports and ports of entry, and regional or remote centres.

"The introduction of a fast, reliable, user-friendly, point-of-care device to diagnose infections and infectious diseases on the spot, and even determine antimicrobial resistance, would be a game-changer for improving targeted patient care," he said.

"c-FIND could prevent patients with hard-to-diagnose or hard-to-detect infections from waiting days, or weeks, for test results to come back whilst having expensive drug treatments, or unnecessary and invasive procedures."

Pandemic preparedness

Professor Pellegrini said the global COVID-19 pandemic had highlighted weaknesses in Australia's ability to quickly detect, diagnose and respond to infectious disease threats.

"The current way that we test for COVID-19 is labour intensive, requiring highly trained staff, a central laboratory and expensive equipment to process samples. It can take days for patients to receive results, increasing the likelihood of disease transmission within the community," Professor Pellegrini said.

"If a system such as c-FIND was available in the market, it could prevent disease spread and save lives by identifying infected people when they are tested so they can be isolated and treated without delay. It is widely accepted that pandemics will become more frequent in the future. A diagnostic device such as c-FIND would advance our capability to successfully respond to these emerging threats."

Peter Mac infectious disease physician and associate director of health services research Professor Karin Thursky said the pandemic had knock-on effects for other parts of the healthcare system, such as cancer care, and significant impacts on vulnerable patients.

"With COVID-19 in the community, cancer patients are at significant risk and hospitals are having to put measures in place to protect them. This has meant that any cancer patient who presents with fever or respiratory symptoms is placed in strict isolation, and treated as COVID-19-positive until they return two negative results. These measures are distressing for patients and their loved ones, cause delays to cancer treatment being able to progress and place an additional burden on the healthcare system," Professor Thursky said.

Once fully developed, the c-FIND diagnostic would involve taking a blood, mucus or saliva sample from a patient and - with minimal preparation - applying this to a small cartridge. This cartridge would then be run through the device to rapidly screen for as many as eight different viral, fungal or bacterial organisms at a time.

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