A UNIQUE snake venom could become a tool in the battle against conditions such as Alzheimer's, Parkinson's, schizophrenia and neuropathic pain.
Griffith University pharmacologist Niru Nirthanan has played a key role in a world-first discovery of an eight-molecule potentially fatal snake venom toxin called fulditoxin from the eastern coral snake Micrurus fulvius fulvius which is found in North and South America.
Associate Professor Niru Nirthanan from Griffith's School of Medical Science has made the discovery with colleagues from the National University of Singapore, University of Queensland, University of Wollongong and HiQScreen in Switzerland.
His research, which has been published in the British Journal of Pharmacology, expands on the team's previous work a decade ago into King Cobra venom and its potential for drug discovery and advancing knowledge of disease mechanisms.
The structure of the King Cobra toxin, haditoxin, consisted of two identical molecules connected like a "conjoint twin," that produced its unique pharmacological actions.
The novel coral snake toxin's structure combines eight identical toxin molecules to form a large "octameric complex".
Professor Nirthanan said it was the first report of a snake venom neurotoxin able to combine to form an eight-unit complex.
"We believe that snakes appear to assemble their toxin molecules together to form complexes, in order to expand their selectivity and potency for protein targets in their prey as well as defense against their predators," Professor Nirthanan said.
"This is a unique strategy employed by the snake to maximise the scope and effectiveness of the toxins in its venom."
Snakes can change the composition of toxins in their venom, depending on the environment, the season or even their diet; and neurotransmitter receptors that regulate communication between nerve cells or between nerves and muscles are a common target.
"Given fulditoxin's ability to specifically target human protein receptors that are clinically significant in neurological and neurodegenerative conditions such as Alzheimer's and Parkinson's diseases, schizophrenia, drug and substance addiction, and neuropathic pain, we postulate that it has potential to be useful as a therapeutic lead or diagnostic tool or molecular probe to aid in these conditions," Professor Nirthanan said.
Compounds derived from natural sources such as animal venoms have played a significant role in drug discovery including that of widely prescribed blood pressure medication, captopril, from a Brazilian viper venom.