COULD testosterone be the elixir of youth for men? Western Australian researchers think so.
Testosterone plays a critical role in male sexual functioning, including modulation of libido, erectile function and production of sperm. It is also converted to estradiol, with higher levels of estradiol associated with longer telomeres, which are proteins that protect chromosomes from damage.
Researchers from the University of WA carried out a study to look at the relationship between sex hormones and ageing in older men. It is the largest study of its kind to date.
The researchers collected data from 2913 men in Perth aged between 70 and 89 and measured both testosterone and estradiol levels in their blood. The length of telomeres in their DNA from white cells was also measured.
The lead scientist of the study, Bu Yeap from UWA Medical School, said the researchers found a correlation between higher estradiol levels and longer telomeres. He said the protection of chromosomes from telomeres that were longer slowed the ageing process.
"The research suggests higher testosterone levels in older men, which is then converted to estradiol, might sustain youthfulness," Professor Yeap said.
"We know from the study that testosterone, estradiol and telomeres are linked, however further research is needed to explore how this relationship works.
"Testosterone is converted to estradiol but it's still unclear what determines the level of production."
Professor Yeap said other factors should also be considered in estradiol levels such as physical activity and body composition.
The research has been supported by the National Health and Medical Research Council of Australia and is published in Clinical Endocrinology.